Publications
Selection of manuscripts from PlaqOmics members from 2013-2020.
Clonally expanding smooth muscle cells promote athero-sclerosis by escaping efferocytosis and activating the comple-ment cascade
Proc Natl Acad Sci U S A. 2020 Jun 15:202006348. doi: 10.1073/pnas.2006348117.
PlaqOmics Leducq Fondation Trans-Atlantic Network.
Owens GK, Pasterkamp G. PlaqOmics Leducq Fondation Trans-Atlantic Network. Circ Res. 2019 Apr 26;124(9):1297-1299. doi:10.1161/CIRCRESAHA.119.314989.
The Emerging Role of the ADAMTS Family in Vascular Diseases
Rienks M, Barallobre-Barreiro J, Mayr M.
Circ Res. 2018 Dec 7;123(12):1279-1281. doi: 10.1161/CIRCRESAHA.118.313737.
Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.
Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S, St Hilaire C,
Müller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK. Nat Med. 2018 Jul 23. doi:
10.1038/s41591-018-0124-5.
A decade of genome-wide association studies for coronary artery disease: The challenges ahead.
Erdmann J, Kessler T, Munoz Venegas L, Schunkert H.
Cardiovasc Res. 2018 Mar 30. doi: 10.1093/cvr/cvy084.
CYP17A1 Deficient XY Mice Display Susceptibility to Atherosclerosis, Altered Lipidomic Profile and Atypical Sex Development
Sci Rep. 2020 May 29;10(1):8792. doi:10.1038/s41598-020-65601-0.
Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus
Nanda V, Wang T, Pjanic M, Liu B, Nguyen T, Matic LP, Hedin U, Koplev S, Ma L, Franzén O, Ruusalepp A, Schadt EE, Björkegren JLM, Montgomery SB, Snyder MP, Quertermous T, Leeper NJ, Miller CL. PLoS Genet. 2018 Nov 16;14(11):e1007755.
Klf4 has an unexpected protective role in peri-vascular cells within the microvasculature
Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK. Am J Physiol Heart Circ Physiol. 2018 Apr 6. doi: 10.1152/ajpheart.00084.2018.
Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds.
Newman AA, Baylis RA, Hess DL, Griffith SD, Shankman LS, Cherepa-nova OA, Owens GK.
JCI Insight. 2018 Aug 9;3(15). pii: 121017. doi: 10.1172/jci.insight.121017.
Associations of autozygosity with a broad range of human phenotypes.
Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease
Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease.
Leeper NJ, Maegdefessel L. Circ Res. 2017 Aug 4;121(4):320-322.
Is there an effect of antithrombotics on carotid intraplaque haemorrhage?
Guo L, Virmani R, Finn AV.
Eur Heart J. 2018 Sep 12. doi: 10.1093/eurheartj/ehy583.
Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.
Suna G, Wojakowski W, Lynch M, Barallobre-Barreiro J, Yin X, Mayr U, Baig F, Lu R, Fava M, Hayward R, Molenaar C, White SJ, Roleder T, Milewski KP, Gasior P,
Buszman PP, Buszman P, Jahangiri M, Shanahan CM, Hill J, Mayr M. Circulation. 2018 Jan 9;137(2):166-183.
Prediction of Causal Candidate Genes in Coronary Artery Disease Loci.
Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët DA, Hao K, Topol EJ, Schadt EE, Yang X, Samani NJ, Björkegren JL, Erdmann J, Schunkert H, Lusis AJ, Leducq Consortium CAD Genomics. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2207-17.
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets.
Lempiäinen H, Brænne I, Michoel T, Tragante V, Vilne B, Webb TR, Kyriakou T, Eichner J, Zeng L, Willen-borg C, Franzen O, Ruusa-lepp A, Goel A, van der Laan SW, Biegert C, Hamby S, Talukdar HA, Foroughi Asl H; CVgenes@target consortium, Pasterkamp G, Watkins H, Samani NJ, Wittenberger T, Erdmann J, Schunkert H, Asselbergs FW, Björkegren JLM. Sci Rep. 2018 Feb 21;8(1):3434.
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombo-spondin-1.
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q,
Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert
H, Aherrahrou Z, Kong W. Circulation. 2015 Mar 31; 131(13):1191-201.
The CANTOS Trial: One Important Step for Clinical Cardiology but a Giant Leap for Vascular Biology.
Baylis RA, Gomez D, Mallat Z, Pasterkamp G, Owens GK. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):e174-e177.
CD163+ macrophages promote angiogenesis and vascular perme-ability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, [28 co-authors], Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV. J Clin Invest. 2018 Feb 19. pii: 93025. doi: 10.1172/JCI93025
Expression quantitative trait loci acting across multiple tissues are enriched in inherited risk for coronary artery disease.
Foroughi H, Talukdar HA, Kindt AS, Jain RK, Ermel R, Ruusalepp A, Nguyen KD, Dobrin R, Reilly DF, Schunkert H, Samani NJ, Braenne I, Erdmann J, Melander O, Qi J, Ivert T, Skogsberg J, Schadt EE, Michoel T, Björkegren JL, CARDIoGRAM Consortium. Circ Cardiovasc Genet. 2015 Apr;8(2):305-15.
Genome-Wide Asso-ciation and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease.
Li Y, Wang DW, [20 co-authors], Wang C, Erdmann J, Zeng L, Huang S, Zhong J, Ma Y, Chen W, Sun J, Lei W, Chen S, Rao S, Gu D, Schunkert H, Tian XL. ATVB. 2018 Feb 22.
Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective.
Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ,
Bekiranov S, Connelly JJ, Tomilin A, Owens GK. Nat Med. 2016 Jun;22(6):657-65.
Proatherosclerotic Effect of the α1-Subunit of Soluble Guanylyl Cyclase by Promoting Smooth Muscle Phenotypic Switching.
Segura-Puimedon M, Mergia E, Al-Hasani J, Aherrahrou R, Stoelting S, Kremer F, Freyer J, Koesling D, Erdmann J, Schunkert H, de Wit C, Aherrahrou Z. Am J Pathol. 2016 Aug;186(8):2220-31.
Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study.
van der Laan SW, Fall T, Soumaré A, Teumer A, Sedaghat S, Baumert J, Zabaneh D, van Setten J, Isgum I, Galesloot TE, Arpegård J, Amouyel P, Trompet S, Waldenberger M, Dörr M, Magnusson PK, Giedraitis V, Larsson A, Morris AP, Felix JF, Morrison AC, Franceschini N, Bis JC, Kavousi M, O'Donnell C, Drenos F, Tragante V, Munroe PB, Malik R, Dichgans M, Worrall BB, Erdmann J, Nelson CP, Samani NJ, Schunkert H, Marchini J, Patel RS, Hingorani AD, [>30 authors], Reiner AP, Ingelsson E, den Ruijter HM, de Bakker PI, Pasterkamp G, Ärnlöv J, Holmes MV, Asselbergs FW. J Am Coll Cardiol. 2016 Aug 30;68(9):934-45.
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.
Miller CL, Pjanic M, Wang T, Nguyen T, Cohain A, Lee JD, Perisic L, Hedin U, Kundu RK, Majmudar D, Kim JB, Wang O, Betsholtz C, Ruusalepp A, Franzén O, Assimes TL, Montgomery SB, Schadt EE, Björkegren JL, Quertermous T.
Nat Commun. 2016 Jul 8;7:12092.
Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease.
Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Björkegren JL. Cell Syst. 2016 Mar 23;2(3):196-208.
Dysfunctional nitric oxide signalling increases risk of myocardial infarction.
Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U; CARDIoGRAM., Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H. Nature. 2013 Dec 19;504(7480):432-6.
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegde-fessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. Nature. 2016 Aug 4;536(7614):86-90.
Functional Characteri-zation of the GUCY1A3 Coronary Artery Disease Risk Locus
Kessler T, Wobst J, Wolf B, Eckhold J, Vilne B, Hollstein R, von Ameln S, Dang
TA, Sager HB, Moritz Rumpf P, Aherrahrou R, Kastrati A, Björkegren JLM, Erdmann
J, Lusis AJ, Civelek M, Kaiser FJ, Schunkert
H. Functional Characterization of
the GUCY1A3 Coronary Artery Disease Risk Locus. Circulation. 2017 Aug
1;136(5):476-489.
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With CAD
Webb T, Erdmann J, [> 50 authors], Samani NJ, Schunkert H, Deloukas P, Kathiresan S, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. JACC. 2017 Volume 69, Issue 7
Human Validation of Genes Associated With a Murine Athero-sclerotic Phenotype.
Pasterkamp G, van der Laan SW, Haitjema S, Foroughi Asl H, Siemelink MA, Bezemer T, van Setten J, Dichgans M, Malik R, Worrall BB, Schunkert H, Samani NJ, de Kleijn DP, Markus HS, Hoefer IE, Michoel T, de Jager SC, Björkegren JLM, den Ruijter HM, Asselbergs FW. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1240-6.
Detection of histone modifications at specific gene loci in single cells in histo-logical sections.
Gomez D, Shankman LS, Nguyen AT, Owens GK. Nat Methods. 2013 Feb;10(2):171-7.
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.
Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl
H, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Giannarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J,
Ruusalepp A, Schadt EE, Björkegren JLM. Science. 2016 Aug 19;353(6301):827-30.